View source for Percutaneous hepatic perfusion


{{Infobox medical intervention
| name         = Percutaneous hepatic perfusion
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| specialty    = oncology
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'''Percutaneous hepatic perfusion''' ('''PHP''') is a regionalized, [[minimally-invasive]] approach to [[cancer]] treatment<ref>{{cite book |last1=Morita |first1=Shane Y. |last2=Balch |first2=Charles M. |last3=Klimberg |first3=V. Suzanne |last4=Pawlik |first4=Timothy M. |last5=Posner |first5=Glenn David |last6=Tanabe |first6=Kenneth K. |title=Textbook of General Surgical Oncology |date=2017 |publisher=McGraw Hill Professional |isbn=9780071793322 |page=169 |url=https://books.google.com/books?id=4Ls1DwAAQBAJ&q=Percutaneous+hepatic+perfusion |accessdate=11 July 2019 |language=en}}</ref> currently undergoing Phase II and Phase III [[clinical trial|clinical testing]].  PHP treats a variety of [[hepatic tumors]] by isolating the [[liver]] and exposing the [[organ (anatomy)|organ]] to high-dose [[chemotherapy]].  As demonstrated in clinical trials, patients treated by PHP can tolerate much higher doses of chemotherapeutic agents than those receiving traditional systemic chemotherapy without increased [[toxicity|toxicities]].{{citation needed|date=July 2019}}

== Procedure ==
Using a system of [[catheters]] and [[Filter (chemistry)|filters]], PHP isolates the liver from the [[circulatory system]] and infuses a chemotherapeutic agent directly to the liver via the [[Common hepatic artery|hepatic artery]].  The venous effluent from the liver is then filtered outside of the body and the filtered blood is returned into the [[jugular vein]].  PHP is a repeatable procedure and can be performed in an [[operating room]] or a [[radiology]] suite under [[local anesthesia|local]] or [[general anesthesia]].{{citation needed|date=July 2019}}

== See also ==
* [[Delcath Systems]]

== References ==
{{reflist}}

==Further reading==
* {{cite journal  |vauthors=Pingpank JF, Libutti SK, Chang R, etal |title=Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies |journal=J. Clin. Oncol. |volume=23 |issue=15 |pages=3465–74 |date=May 2005 |pmid=15908655 |pmc=2374756 |doi=10.1200/JCO.2005.00.927 |url=http://www.jco.org/cgi/pmidlookup?view=long&pmid=15908655}}
* {{cite journal |vauthors=Seidel GD, Locklin J, Muehlbauer PM |title=Part I: regional chemotherapy clinical studies in nontraditional clinical settings |journal=Clin J Oncol Nurs |volume=10 |issue=3 |pages=338–44 |date=June 2006 |pmid=16789579 |doi=10.1188/06.CJON.338-344 |url=http://ons.metapress.com/openurl.asp?genre=article&id=doi:10.1188/06.CJON.338-344}}
{{Medicine|state=collapsed}}
[[Category:Hepatology]]
[[Category:Cancer treatments]]


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