Ciliary neurotrophic factor receptor
Protein complex
The ciliary neurotrophic factor receptor, also known as CNTFR, binds the ciliary neurotrophic factor. This receptor and its cognate ligand support the survival of neurons.[1] This receptor is most closely related to the interleukin-6 receptor. This receptor possesses an unusual attachment to the cell membrane through a glycophosphatidylinositol linkage.[2]
| ciliary neurotrophic factor receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CNTFR | ||||||
| NCBI gene | 1271 | ||||||
| HGNC | 2170 | ||||||
| OMIM | 118946 | ||||||
| RefSeq | NM_001842 | ||||||
| UniProt | P26992 | ||||||
| Other data | |||||||
| Locus | Chr. 9 p13 | ||||||
| |||||||
References
- ^ Davis S, Aldrich TH, Valenzuela DM, Wong VV, Furth ME, Squinto SP, Yancopoulos GD (1991). "The receptor for ciliary neurotrophic factor". Science. 253 (5015): 59–63. Bibcode:1991Sci...253...59D. doi:10.1126/science.1648265. PMID 1648265.
- ^ Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD, Wiegand SJ (2000). "The ciliary neurotrophic factor and its receptor, CNTFR alpha". Pharm Acta Helv. 74 (2–3): 265–72. doi:10.1016/S0031-6865(99)00050-3. PMID 10812968.
External links
- Ciliary+Neurotrophic+Factor+Receptor+alpha+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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