Ectonucleoside triphosphate diphosphohydrolase 7
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Ectonucleoside triphosphate diphosphohydrolase 7 is a protein that in humans is encoded by the ENTPD7 gene.[1]
Function
This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017].
References
- ^ "Entrez Gene: Ectonucleoside triphosphate diphosphohydrolase 7". Retrieved 2018-05-11.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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