File:MiRNA processing.JPG

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Summary

Description
English: Overview of microRNA processing in animals, from transcription to the formation of the effector complex.

Enzymes:
Pol II (transcription) and associated proteins
Drosha, Pasha (pri-miRNA → pre-miRNA)
RAN-GTP, Exportin-5 (export from nucleus)
Dicer (pre-miRNA → miRNA)
RISC (effector complex)

Abbrevations:
pri-miRNA = primary microRNA transcript
pre-miRNA = precursor microRNA
miRNA = microRNA
miRNA* = antisense microRNA
miRISC = microRNA-induced silencing complex
Date
Source Self-made, based on an illustration in Esquela-Kerscher A, Slack FJ (2006). "Oncomirs — microRNAs with a role in cancer". Nature Reviews Cancer 6 (4): 259–69. DOI:10.1038/nrc1840. PMID 16557279.
Author w:User:Narayanese
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inception

9 January 2008

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current21:38, 24 July 2008Thumbnail for version as of 21:38, 24 July 2008838 × 1,496 (211 KB)wikimediacommons>Narayaneseoops, was supposed to be 3' overhang, fixed now

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