GRAM domain-containing 2B
Protein encoded by the GRAMD2B gene
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GRAM domain-containing 2B protein (GRAMD2B; formerly GRAMD3), also known as NS3TP2 and HCV NS3-transactivated protein 2 is a protein encoded by the GRAMD2B gene.[1][2]
GRAMD2B has four paralogs: GRAMD1A, GRAMD1B, GRAMD1C and GRAMD2A. These proteins are mammalian representatives of the yeast lipid transfer proteins anchored at a membrane contact site (LAM) family.[3]
GRAMD2B consists of a GRAM domain and a transmembrane domain anchoring it to the endoplasmic reticulum.[4][3] Similar to GRAMD2A, GRAMD2B lacks the VASt domain found in LAM and GRAMD1 proteins. Its function has not yet been defined, but is likely similar to that of GRAMD2A.
References
- ^ "GRAMD2B GRAM domain containing 2B [ Homo sapiens (human) ]". Retrieved March 7, 2020.
- ^ "UniProtKB - Q96HH9 (GRM2B_HUMAN)". Retrieved March 7, 2020.
- ^ 3.0 3.1 Besprozvannaya M, Dickson E, Li H, Ginburg KS, Bers DM, Auwerx J, Nunnari J (February 2018). "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells". eLife. 22 (7): e31019. doi:10.7554/eLife.31019. PMC 5823543. PMID 29469807.
- ^ "RecName: Full=GRAM domain-containing protein 2A)". Retrieved March 7, 2020.