N-Terminal domain antiandrogen

See also: Discovery and development of antiandrogens § N-Terminal domain antagonists

N-Terminal domain antiandrogen
Drug class
EPI-001, the first major N-terminal domain AR antagonist to be developed.
Class identifiers
Synonyms	N-Terminal domain AR antagonists; AR NTD antagonists
Use	Prostate cancer
Biological target	Androgen receptor
Legal status

N-Terminal domain antiandrogens are a novel type of antiandrogen that bind to the N-terminal domain of the androgen receptor (AR) instead of the ligand-binding domain (where all currently-available antiandrogens bind) and disrupt interactions between the AR and its coregulatory binding partners, thereby blocking AR-mediated gene transcription. They are being investigated for the treatment of prostate cancer.

See also

• Androgen deprivation therapy
• 5N-Bicalutamide