Androvax

Androvax
Combination of
Androstendione	Androstane steroid
Human serum albumin	Serum protein
Clinical data
Trade names	Androvax
Other names	Androstenedione:human serum albumin conjugate
AHFS/Drugs.com	Monograph
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	128280-53-5;
ChemSpider	None;

Androvax, also known as androstenedione:human serum albumin conjugate, is an immunogen and vaccine against androstenedione that is used in veterinary medicine to increase the ovulation rate and number of lambs born to ewes.^[1]^[2]^[3] It is a conjugate of androstenedione and human serum albumin.^[1]^[3] The drug is marketed in New Zealand.^[1]^[3]

Androvax produces immunity against androstenedione, and the generation of antibodies against androstenedione decreases circulating levels of androstenedione.^[1] In addition, since androstenedione is the major precursor of estrogens, estrogen levels are decreased as well.^[1] This is thought to result in reduced negative feedback on the hypothalamic-pituitary-gonadal axis and increased gonadotropin secretion, which in turn improves fertility and fecundity.^[1]

References

^ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Jindal SK, Sharma MC (2010). Biotechnology in Animal Health and Production. New India Publishing. pp. 77–. ISBN 978-93-80235-35-6.
^ Reproductive Technologies in Farm Animals. CABI. 2004. pp. 206–. ISBN 978-0-85199-049-1.
^ ^3.0 ^3.1 ^3.2 "Androvax Label" (PDF). Schering-Plough Animal Health Ltd. MSD Animal Health.

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