INPP5F

An Error has occurred retrieving Wikidata item for infobox

Inositol polyphosphate-5-phosphatase F is a protein that in humans is encoded by the INPP5F gene.

Function

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].

Further reading

• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA (December 2009). "Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness". Circ. Res. 105 (12): 1240–7. doi:10.1161/CIRCRESAHA.109.208785. PMC 2802340. PMID 19875726.
• Kim HS, Li A, Ahn S, Song H, Zhang W (December 2014). "Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity". Sci Rep. 4: 7330. Bibcode:2014NatSR...4E7330K. doi:10.1038/srep07330. PMC 4256660. PMID 25476455.
• Hsu F, Hu F, Mao Y (April 2015). "Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling". J. Cell Biol. 209 (1): 97–110. doi:10.1083/jcb.201408027. PMC 4395482. PMID 25869669.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.