LCORL

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Ligand dependent nuclear receptor corepressor like is a protein that in humans is encoded by the LCORL gene.

Function

This gene encodes a transcription factor that appears to function in spermatogenesis. Polymorphisms in this gene are associated with measures of skeletal frame size and adult height. Alternative splicing results in multiple transcript variants.

Further reading

• Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1)". FEBS Lett. 535 (1–3): 61–5. doi:10.1016/s0014-5793(02)03858-9. PMID 12560079. S2CID 83745027.
• Sovio, U; Bennett, AJ; Millwood, IY; Molitor, J; O'Reilly, PF; Timpson, NJ; Kaakinen, M; Laitinen, J; Haukka, J; Pillas, D; Tzoulaki, I; Molitor, J; Hoggart, C; Coin, LJ; Whittaker, J; Pouta, A; Hartikainen, AL; Freimer, NB; Widen, E; Peltonen, L; Elliott, P; McCarthy, MI; Jarvelin, MR (March 2009). "Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966". PLOS Genetics. 5 (3): e1000409. doi:10.1371/journal.pgen.1000409. PMC 2646138. PMID 19266077.
• Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB, Hammond N, Stolk L, Nica A, Inouye M, Hofman A, Stephens J, Wheeler E, Arp P, Gwilliam R, Jhamai PM, Potter S, Chaney A, Ghori MJ, Ravindrarajah R, Ermakov S, Estrada K, Pols HA, Williams FM, McArdle WL, van Meurs JB, Loos RJ, Dermitzakis ET, Ahmadi KR, Hart DJ, Ouwehand WH, Wareham NJ, Barroso I, Sandhu MS, Strachan DP, Livshits G, Spector TD, Uitterlinden AG, Deloukas P (2009). "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size". PLOS Genet. 5 (4): e1000445. doi:10.1371/journal.pgen.1000445. PMC 2661236. PMID 19343178.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.