MBOAT7
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Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene.[1] It is homologous to other membrane-bound O-acyltransferases.[2][3]
Function
This gene encodes a member of the membrane-bound O-acyltransferase family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle.[1][2]
References
- ^ 1.0 1.1 "Entrez Gene: Membrane bound O-acyltransferase domain containing 7".
- ^ 2.0 2.1 Shindou H, Shimizu T (2009). "Acyl-CoA:Lysophospholipid Acyltransferases". Journal of Biological Chemistry. 284 (1): 1–5. doi:10.1074/jbc.R800046200. PMID 18718904.
- ^ Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Lao M, Walther TC, Farese Jr RV (2023). "The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification". Nature Communications. 14 (1): 3533. Bibcode:2023NatCo..14.3533W. doi:10.1038/s41467-023-38932-5. PMC 10267149. PMID 37316513. Art. No. 3533.
Further reading
- Wende H, Volz A, Ziegler A (July 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
- Lee HC, Inoue T, Imae R, Kono N, Shirae S, Matsuda S, Gengyo-Ando K, Mitani S, Arai H (March 2008). "Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol". Mol. Biol. Cell. 19 (3): 1174–84. doi:10.1091/mbc.E07-09-0893. PMC 2262980. PMID 18094042.
- Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T (April 2009). "Recent progress on acyl CoA: lysophospholipid acyltransferase research". J. Lipid Res. 50 Suppl (Suppl): S46–51. doi:10.1194/jlr.R800035-JLR200. PMC 2674719. PMID 18931347.
- Gijón MA, Riekhof WR, Zarini S, Murphy RC, Voelker DR (October 2008). "Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils". J. Biol. Chem. 283 (44): 30235–45. doi:10.1074/jbc.M806194200. PMC 2573059. PMID 18772128.
- Fukunaga-Johnson N, Lee SW, Liebert M, Grossman HB (1996). "Molecular analysis of a gene, BB1, overexpressed in bladder and breast carcinoma". Anticancer Res. 16 (3A): 1085–90. PMID 8702217.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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