UNC5A
An Error has occurred retrieving Wikidata item for infobox Netrin receptor UNC5A is a protein that in humans is encoded by the UNC5A gene.[1]
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM][1]
Interactions
UNC5A has been shown to interact with MAGED1.[2]
References
- ^ 1.0 1.1 "Entrez Gene: UNC5A unc-5 homolog A (C. elegans)".
- ^ Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
Further reading
- Arakawa H (December 2004). "Netrin-1 and its receptors in tumorigenesis". Nature Reviews. Cancer. 4 (12): 978–87. doi:10.1038/nrc1504. PMID 15573119. S2CID 867903.
- Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Nagase T, Kikuno R, Ohara O (December 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
- Williams ME, Strickland P, Watanabe K, Hinck L (May 2003). "UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NRAGE". The Journal of Biological Chemistry. 278 (19): 17483–90. doi:10.1074/jbc.M300415200. PMID 12598531.
- Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (March 2003). "p53RDL1 regulates p53-dependent apoptosis". Nature Cell Biology. 5 (3): 216–23. doi:10.1038/ncb943. PMID 12598906. S2CID 7017409.
- Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, et al. (April 2003). "The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment". Proceedings of the National Academy of Sciences of the United States of America. 100 (7): 4173–8. Bibcode:2003PNAS..100.4173T. doi:10.1073/pnas.0738063100. PMC 153067. PMID 12655055.
- Geisbrecht BV, Dowd KA, Barfield RW, Longo PA, Leahy DJ (August 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". The Journal of Biological Chemistry. 278 (35): 32561–8. doi:10.1074/jbc.M302943200. PMID 12810718.
- Llambi F, Lourenço FC, Gozuacik D, Guix C, Pays L, Del Rio G, et al. (March 2005). "The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase". The EMBO Journal. 24 (6): 1192–201. doi:10.1038/sj.emboj.7600584. PMC 556396. PMID 15729359.
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