Ubiquitin-fold modifier conjugating enzyme 1

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Ubiquitin-fold modifier conjugating enzyme 1 is a protein that in humans is encoded by the UFC1 gene.

Function

UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008].

Further reading

• Komatsu M, Chiba T, Tatsumi K, Iemura S, Tanida I, Okazaki N, Ueno T, Kominami E, Natsume T, Tanaka K (May 2004). "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier". EMBO J. 23 (9): 1977–86. doi:10.1038/sj.emboj.7600205. PMC 404325. PMID 15071506.
• Liu G, Forouhar F, Eletsky A, Atreya HS, Aramini JM, Xiao R, Huang YJ, Abashidze M, Seetharaman J, Liu J, Rost B, Acton T, Montelione GT, Hunt JF, Szyperski T (April 2009). "NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway". J. Struct. Funct. Genomics. 10 (2): 127–36. doi:10.1007/s10969-008-9054-7. PMC 2850604. PMID 19101823.
• Homrich M, Wobst H, Laurini C, Sabrowski J, Schmitz B, Diestel S (June 2014). "Cytoplasmic domain of NCAM140 interacts with ubiquitin-fold modifier-conjugating enzyme-1 (Ufc1)". Exp. Cell Res. 324 (2): 192–9. doi:10.1016/j.yexcr.2014.04.003. PMID 24726913.
• Xie S (August 2014). "Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex". Acta Crystallogr F. 70 (Pt 8): 1093–7. doi:10.1107/S2053230X14014502. PMC 4118812. PMID 25084390.
• Tellermann A, Witte T, Lansche C, Stoll M, Schmidt RE, Baerlecken NT (February 2015). "Autoantibodies binding to ubiquitin-fold modifier-conjugating enzyme 1 (Ufc1) and pleckstrin homology domain containing, family G (with RhoGef domain) member 2 (Plekhg2) are associated with mycobacterial infections". HIV Med. 16 (2): 114–21. doi:10.1111/hiv.12194. PMID 25213431.
• Cao C, Sun J, Zhang D, Guo X, Xie L, Li X, Wu D, Liu L (February 2015). "The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells". Gastroenterology. 148 (2): 415–26.e18. doi:10.1053/j.gastro.2014.10.012. PMID 25449213.
• Zhang G, Wu Y, Xu D, Yan X (November 2016). "Long Noncoding RNA UFC1 Promotes Proliferation of Chondrocyte in Osteoarthritis by Acting as a Sponge for miR-34a". DNA Cell Biol. 35 (11): 691–695. doi:10.1089/dna.2016.3397. PMID 27529373.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.